Primary esophageal and gastro-esophageal junction cancer xenograft models: clinicopathological features and engraftment
نویسندگان
چکیده
منابع مشابه
Appropriateness of Using Patient-Derived Xenograft Models for Pharmacologic Evaluation of Novel Therapies for Esophageal/Gastro-Esophageal Junction Cancers
The high morbidity and mortality of patients with esophageal (E) and gastro-esophageal junction (GEJ) cancers, warrants new pre-clinical models for drug testing. The utility of primary tumor xenografts (PTXGs) as pre-clinical models was assessed. Clinicopathological, immunohistochemical markers (p53, p16, Ki-67, Her-2/neu and EGFR), and global mRNA abundance profiles were evaluated to determine...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2013
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.2013.8